The brain's cleaning system can be boosted to rid Alzheimer's proteins
March 25, 2026
News & Publications
Press
Study Links Sleep to Overnight Clearing of Alzheimer’s-Linked Proteins
February 24, 2026
New Study Shows Sleep May Help Clear Alzheimer’s‑Linked Proteins From the Brain—Here’s What That Means
February 3, 2026
Preventing Alzheimer's May Start at Night: Study Links Sleep to Overnight Clearing of Alzheimer's-Linked Proteins
January 27, 2026
Glymphatic System Clears Amyloid Beta, Tau in Humans
January 27, 2026
A Novel Wireless Device Measures Continuous Glymphatic Function During Sleep
August 21, 2025
Wearable Device Tracks Brain Waste System
May 29, 2025
Human study tracks brain’s glymphatic flow in real time, opening Alzheimer’s drug avenues
May 27, 2025
Applied Cognition Publishes First-in-Human Study of Glymphatic Function in Nature Biomedical Engineering
May 27, 2025
Publications & Presentations
Pharmacological enhancement of glymphatic function in humans increases the clearance of Alzheimer’s disease-related proteins
Paul Dagum, Brieann C. Satterfield, Laurent Giovangrandi, T. Robert Feng, Alejandro Corbellini, Kevin Yarasheski, Brendan P. Lucey, Hans Van Dongen, Jeffrey J. Iliff, Albert T. Cheung
March, 2026
Nature Communications -- The glymphatic system clears amyloid beta and tau from brain to plasma in humans
Paul Dagum, Donald L. Elbert, Laurent Giovangrandi, Tarandeep Singh, Venky V. Venkatesh, Alejandro Corbellini, Robert M. Kaplan, Swati Rane Levendovszky, Elizabeth Ludington, Kevin Yarasheski, Jeffrey Lowenkron, Carla VandeWeerd, Miranda M. Lim, Jeffrey J. Iliff
January, 2026
Nature Biomedical Engineering -- A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans
Paul Dagum, Laurent Giovangrandi, Swati Rane Levendovszky, Jake J. Winebaum, Tarandeep Singh, Yeilim Cho, Robert M. Kaplan, Michael S. Jaffee, Miranda M. Lim, Carla Vandeweerd and Jeffrey J. Iliff
May, 2025
Glymphatic flow resistance in humans measured by multifrequency impedance dispersion
Paul Dagum, Laurent Giovangrandi, Swati Rane Levendovszky, Jake J. Winebaum, Tarandeep Singh, Yeilim Cho, Robert M. Kaplan, Michael S. Jaffee, Miranda M. Lim, Carla Vandeweerd, Jeffrey J. Iliff
September, 2024
SLEEP 2024 - Measuring the Resistance to Glymphatic Flow in Humans
Paul Dagum
June, 2024
MHSRS 2023 - Development and Validation of a Wearable Device for Continuous Assessment and Measurement of Sleep-Associated Cranial Fluid Dynamics and EEG
Paul Dagum, Laurent Giovangrandi, Jacob Winebaum, Juan Piantino, Miranda M. Lim, Jeffrey Iliff
August, 2023
AAIC 2023 - Comparison of IVIM MRI measures of brain fluid transport against contrast-enhanced MRI in the setting of sleep deprivation
Swati Rane, Carla Vanderweerd, Mitchell Roberts, Tarandeep Singh, Alejandro Corbellini, Cole Anderson, Juan Piantino, Miranda M. Lim, Paul Dagum, Jeffrey Iliff
July 2023
AAIC 2023 - Noninvasive and remote measurement of sleep-active glymphatic function in the human brain by dynamic impedance spectro-tomography
Jeffrey Iliff, Swati Rane Levendovszky, Carla Vanderweerd, Michael Jaffe, Jeffrey Lowenkron, Tarandeep Singh, Laurent Giovangrandi, Miranda M. Lim, Paul Dagum
July 2023
SLEEP 2023 - A wearable device for continuous assessment and measurement of sleep cranial fluid dynamics and EEG
Laurent Giovangrandi, Shilpa Balakrishnan, Juan Piantino, Miranda M Lim, Jeffrey Iliff, Paul Dagum
June 2023